Post-exposure therapy of inhalational anthrax in the common marmoset
نویسندگان
چکیده
منابع مشابه
Raxibacumab for the treatment of inhalational anthrax.
BACKGROUND Inhalational anthrax caused by Bacillus anthracis is associated with high mortality primarily due to toxin-mediated injury. Raxibacumab is a human IgG1lambda monoclonal antibody directed against protective antigen, a component of the anthrax toxin. METHODS We evaluated the efficacy of raxibacumab as a prophylactic agent and after disease onset in a total of four randomized, placebo...
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The intracellular Gram-negative pathogen Francisella tularensis is the causative agent of tularaemia and is prevalent in many countries in the northern hemisphere. To determine whether the common marmoset (Callithrix jacchus) would be a suitable non-human primate model of inhalational tularaemia, a pathophysiology study was undertaken. Ten animals were challenged with approximately 10(2) c.f.u....
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References 1 Cykert S, Kissling G, Hansen CJ. Patient preferences regarding possible outcomes of lung resection: what outcomes should preoperative evaluations target? Chest 2000; 117: 1551–1559. 2 Ware JE Jr, Sherbourne CD. The MOS 36-items short form health survey (SF36). I. Conceptual framework and item selection. Med Care 1992; 30: 473–483. 3 Cohen J. Statistical Power Analysis for the Behav...
متن کاملInhalational , Gastrointestinal , and Cutaneous Anthrax in Children
Results: Of 2499 potentially relevant articles, 73 case reports of pediatric anthrax (5 inhalational cases, 22 gastrointestinal cases, 37 cutaneous cases, 6 cases of primary meningoencephalitis, and 3 atypical cases) met the inclusion criteria. Only 10% of the patients were younger than 2 years, and 24% were girls. Of the few children with inhalational anthrax, none had nonheadache neurologic s...
متن کاملClinical predictors of bioterrorism-related inhalational anthrax.
Limitation of a bioterrorist anthrax attack will require rapid and accurate recognition of the earliest victims. To identify clinical characteristics of inhalational anthrax, we compared 47 historical cases (including 11 cases of bioterrorism-related anthrax) with 376 controls with community-acquired pneumonia or influenza-like illness. Nausea, vomiting, pallor or cyanosis, diaphoresis, altered...
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ژورنال
عنوان ژورنال: International Journal of Antimicrobial Agents
سال: 2011
ISSN: 0924-8579
DOI: 10.1016/j.ijantimicag.2011.03.003